Cholesterol is more than a number—it’s your immune ally.
Is Low Cholesterol Really Good?
We’ve all heard that lowering cholesterol is key to a long, healthy life. But recent research suggests that very low cholesterol might actually increase your risk of death—especially from infections. Surprised? You’re not alone.
Cholesterol’s Real Role in the Body
Cholesterol isn’t just fat in your blood—it’s essential. It builds cell membranes, makes hormones, supports brain function, and even fights infections. LDL and HDL are not just “bad” or “good” cholesterol. They both play crucial roles in transporting and neutralizing harmful substances, including toxic byproducts from bacteria and viruses.
Low Cholesterol and Increased Risk of Infection
Several large-scale studies show a clear correlation between low cholesterol levels and increased risk of respiratory, gastrointestinal, and even viral infections. In fact, one study found that people with total cholesterol under 160 mg/dL had:
- 21% higher infection-related death in men
- 85% higher risk in women
This suggests that lowering cholesterol indiscriminately could make the body more vulnerable to infections, especially in the elderly.
Cholesterol and COVID-19: What We’ve Learned
During the COVID-19 pandemic, researchers in China, Korea, and the U.S. consistently found that patients with lower LDL, HDL, and total cholesterol levels had more severe disease and higher mortality rates. In one study, patients who recovered showed cholesterol levels that rebounded over time. Meanwhile, those who died had continuously falling cholesterol throughout hospitalization.
LDL: More Than Just “Bad” Cholesterol
LDL is often vilified, but it plays a protective role by binding and neutralizing bacterial toxins like lipopolysaccharides (LPS). When LDL drops too low, your immune system may lose this first line of defense—leaving you exposed when you need protection most.
Could Low Cholesterol Be a Red Flag?
The data is compelling: low cholesterol isn’t always a sign of good health. It may reflect malnutrition, chronic inflammation, or an impaired immune system. Especially during active infection, falling cholesterol may be a warning that your body is losing its ability to fight back.
How to Support Cholesterol and Immunity the Smart Way
- Don’t over-restrict dietary cholesterol unless medically necessary
- Eat nutrient-rich, whole foods (not ultra-processed low-fat snacks)
- Support liver health—it regulates 80% of cholesterol production
- Get enough sleep, reduce chronic stress, and avoid excessive sugar
- Track inflammation markers like CRP and hs-CRP with your doctor
Final Thoughts: Reframe the Conversation
Cholesterol isn’t the enemy. In many cases, it’s a vital immune tool. Before celebrating low cholesterol numbers, ask: “Is this helping or hurting my resilience?” Your health isn’t just about being low—it’s about being strong and balanced.
—SELFLOVECLUB Team